Publications
Publications from recent to oldest:
Programming tissue-sensing T cells that deliver therapies to the brain.
Simic, M.S.*, Watchmaker, P.B.*, Gupta, S., Wang, Y., Sagan, S.A., Duecker, J., Shepherd, C., Diebold, D., Pineo-Cavanaugh, P., Haegelin, J., et al. (2024). Science 386, eadl4237. https://doi.org/10.1126/science.adl4237
Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs.
Reddy, N.R., Maachi, H., Xiao, Y., Simic, M.S., Yu, W., Tonai, Y., Cabanillas, D.A., Serrano-Wu, E., Pauerstein, P.T., Tamaki, W., et al. (2024). Science 386, eadl4793. https://doi.org/10.1126/science.adl4793
CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Gupta, S., Simic, M., Sagan, S.A., Shepherd, C., Duecker, J., Sobel, R.A., Dandekar, R., Wu, G.F., Wu, W., Pak, J.E., et al. (2023). Neurol. - Neuroimmunol. Neuroinflammation 10. https://doi.org/10.1212/NXI.0000000000200080
Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.
Daniels, K.G., Wang, S., Simic, M.S., Bhargava, H.K., Capponi, S., Tonai, Y., Yu, W., Bianco, S., and Lim, W.A. (2022). Science 378, 1194–1200. https://doi.org/10.1126/science.abq0225
Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling.
Jullié, D., Benitez, C., Knight, T.A., Simic, M.S., and von Zastrow, M. (2022). eLife 11, e81298. https://doi.org/10.7554/eLife.81298
SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma.
Choe, J.H.*, Watchmaker, P.B.*, Simic, M.S.*, Gilbert, R.D., Li, A.W., Krasnow, N.A., Downey, K.M., Yu, W., Carrera, D.A., Celli, A., et al. (2021). Sci. Transl. Med. 13. https://doi.org/10.1126/scitranslmed.abe7378
The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER
Schinzel, R.T.*, Higuchi-Sanabria, R.*, Shalem, O.*, Moehle, E.A., Webster, B.M., Joe, L., Bar-Ziv, R., Frankino, P.A., Durieux, J., Pender, C., Kelet, N., Kumar, S.S., Savalia, N., Chi, H., Simic, M.S., Nguyen, N., Dillin, A. (2019).. Cell 179, 1306-1318.e18. https://doi.org/10.1016/j.cell.2019.10.018
Prostaglandin signals from adult germline stem cells delay somatic ageing of Caenorhabditis elegans.
Lee, H.J., Noormohammadi, A., Koyuncu, S., Calculli, G., Simic, M.S., Herholz, M., Trifunovic, A., and Vilchez, D. (2019). Nat. Metab., 1–21. https://doi.org/10.1038/s42255-019-0097-9
Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming.
Simic, M.S., Moehle, E.A., Schinzel, R.T., Lorbeer, F.K., Halloran, J.J., Heydari, K., Sanchez, M., Jullié, D., Hockemeyer, D., and Dillin, A. (2019). Sci. Adv. 5, eaaw0025. https://doi.org/10.1126/sciadv.aaw0025
Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response.
Kim, H.-E., Grant, A.R., Simic, M.S., Kohnz, R.A., Nomura, D.K., Durieux, J., Riera, C.E., Sanchez, M., Kapernick, E., Wolff, S., et al. (2016). Cell 166, 1539-1552.e16. https://doi.org/10.1016/j.cell.2016.08.027
Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.
Douglas, P.M.*, Baird, N.A.*, Simic, M.S., Uhlein, S., McCormick, M.A., Wolff, S.C., Kennedy, B.K., and Dillin, A. (2015). Cell Rep. 12, 1196–1204. https://doi.org/10.1016/j.celrep.2015.07.026
HSF-1–mediated cytoskeletal integrity determines thermotolerance and life span.
Baird, N.A.*, Douglas, P.M.*, Simic, M.S., Grant, A.R., Moresco, J.J., Wolff, S.C., Yates, J.R., Manning, G., and Dillin, A. (2014). Science 346, 360–363. https://doi.org/10.1126/science.1253168
Proteostasis and aging of stem cells.
Vilchez, D.*, Simic, M.S.*, and Dillin, A. (2014). Trends Cell Biol. 24, 161–170. https://doi.org/10.1016/j.tcb.2013.09.002
(* equal contribution)